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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Characterization of intercellular communication and mitochondrial donation by mesenchymal stromal cells derived from the human lung

Fig. 3

BM-MSCs, LT-MSCs and BAL-MSCs donate cytoplasmic contents to BEAS2B epithelial cells via multiple mechanisms. Bone marrow-derived mesenchymal stromal cells (BM-MSCs, a), lung tissue-derived mesenchymal stromal cells (LT-MSCs, b) and bronchoalveolar fluid-derived mesenchymal stromal cells (BAL-MSCs, c) were co-cultured with BEAS2B epithelial cells and treated with either dynasore to inhibit endocytosis, cytochalasin D to inhibit microtubule/TNT formation, carbenoxolone to inhibit all gap junction formation or GAP26 to inhibit connexin-43 gap junction formation. Y axis represents this change in mean fluorescent intensity (MFI, %) relative to paired, uninhibited control. Horizontal line represents median. Groups were compared using the Mann–Whitney U test. *p < 0.05 compared with baseline

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Stem Cell Research & Therapy

ISSN: 1757-6512