TGFβ-induced switch from adipogenic to osteogenic differentiation of human mesenchymal stem cells: identification of drug targets for prevention of fat cell differentiation

Table 1 Selected genes involved in adipogenic differentiation

Gene name	Protein function	Inhibitor	Effect
ADAMTS5	Metalloproteinase	Batimastat	Positive
AGTR1	Angiotensin II receptor	Losartan	Negative
AKR1B10	Aldo-keto reductase	Zopolrestat	Positive
BDKRB2	Bradykinin receptor B2	Icatibant	Negative
CXCL12	Chemokine SDF-1	(Not tested)	(Not tested)
KCNK3	Potassium channel	Doxapram	Negative
PPARG	Nuclear receptor	GW9662	Positive
PRKAR2B	cAMP protein kinase	(Not tested)	(Not tested)
VCAM1	Vascular cell adhesion	(Not tested)	(Not tested)

Table presents the HUGO name, function, commercially available drug, and status of experimentally observed effects
positive observed effect, negative no observed effect

ISSN: 1757-6512