Table 3 Top diseases and biological functions from the IPA knowledge base that involve proteins differentially expressed in young compared with old chondrogenic, tenogenic and osteogenic constructs classified as diseases and disorders, molecular and cellular functions and physiological system development and function

Diseases and disorders

 Chondrogenic^a

Inflammatory Response

1.14E-03 - 1.05E-08

34

Developmental Disorder

7.11E-04 - 5.32E-08

33

Skeletal and Muscular Disorders

5.85E-04 - 5.32E-08

46

Cancer

1.21E-03 - 1.37E-07

112

Organismal Injury and Abnormalities

1.21E-03 - 1.37E-07

113

 Tenogenic^a

Cancer

1.26E-18 - 1.84E-03

173

Organismal Injury and Abnormalities

1.26E-18 - 1.96E-03

136

Reproductive System Disease

1.26E-18 - 1.84E-03

104

Immunological Disease

2.13E-12 - 5.18E-04

61

Respiratory Disease

2.78E-12 - 3.26E-04

48

 Osteogenic^b

Infectious Disease

2.00E-05 - 1.54E-02

19

Developmental Disorder

4.83E-05 - 1.14E-02

8

Hereditary Disorder

4.83E-05 - 1.25E-02

11

Metabolic Disease

4.83E-05 - 1.14E-02

10

Neurological Disease

4.83E-05 - 1.77E-02

18

Molecular and cellular functions

 Chondrogenic^a

Cell Death and Survival

1.05E-03 - 2.51E-15

67

Cell Morphology

1.21E-03 - 7.47E-14

50

Cellular Movement

1.24E-03 - 8.51E-12

52

Cell-To-Cell Signalling and Interaction

1.21E-03 - 8.55E-12

45

Cellular Assembly and Organization

1.24E-03 - 8.63E-12

49

 Tenogenic^a

Cellular Movement

3.79E-20 - 2.14E-03

85

Cellular Growth and Proliferation

1.50E-18 - 1.91E-03

109

Cell Death and Survival

1.91E-15 - 2.04E-03

98

Cellular Assembly and Organization

1.62E-14 - 2.20E-03

85

Cellular Function and Maintenance

1.62E-14 - 2.20E-03

87

 Osteogenic^b

Cell Morphology

2.33E-06 - 1.71E-02

19

Lipid Metabolism

2.42E-05 - 1.71E-02

6

Small Molecule Biochemistry

2.42E-05 - 1.72E-02

17

Molecular Transport

2.94E-05 - 1.71E-02

22

Protein Trafficking

2.94E-05 - 2.94E-02

5

Physiological system development and function

 Chondrogenic^a

Connective Tissue Development and Function

1.21E-03 - 2.75E-10

45

Tissue Development

1.24E-03 - 3.83E-09

60

Organismal Survival

1.18E-04 - 7.09E-09

47

Haematological System Development and Function

1.24E-03 - 1.05E-08

29

Immune Cell Trafficking

1.24E-03 - 1.05E-08

27

 Tenogenic^a

Tissue Development

1.98E-08 - 2.22E-03

79

Haematological System Development and Function

1.25E-07 - 1.47E-03

35

Immune Cell Trafficking

1.25E-07 - 1.47E-03

32

Cardiovascular System Development and Function

2.08E-07 - 2.11E-03

30

Skeletal and Muscular System Development and Function

3.87E-07 - 2.11E-03

47

 Osteogenic^b

Nervous System Development and Function

2.33E-06 - 1.80E-02

12

Organ Morphology

7.75E-05 - 1.71E-02

15

Reproductive System Development and Function

7.75E-05 - 1.71E-02

7

Tissue Development

1.15E-04 - 1.71E-02

16

Cardiovascular System Development and Function

2.05E-04 - 1.59E-02

14