Fig. 3

Upregulation of gene expression of AMSCs under hypoxia in both RVD and healthy individuals: hypoxia upregulated pro-survival genes (CDKN1A, HMOX1, TMEM45A, CA9, SLC2A1/ GLUT1, and the autophagy regulatory gene BNIP3) (a). Hypoxia upregulated pro-angiogenic genes (ANGPTL4 and VEGF-a) (b) and (STC1, STC2, and FGF2) (c). RVD renovascular disease