Fig. 2

In vivo modulation of hepatic macrophages expression profile by MSCs. mRNA expression levels of the nitric oxide production mediators arginase-1 and iNOS (a) and IL-10 and pro-fibrogenic cytokines TGF-β1, IL-6, TNF-α, and IL-1bβ (b) in macrophages at 1 day after saline (white bars), AdGFP-MSCs (gray) and AdIGF-I-MSCs (black) treatments. c IL-12 protein levels in hepatic macrophages supernatants relative to macrophages/saline condition. ANOVA Tukey’s post-test, ^* p < 0.05; ^** p < 0.01 and ^*** p < 0.001 vs. macrophages/saline condition; ^σ p < 0.05 and ^σσ p < 0.01 vs. macrophages/AdGFP-MSCs condition