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Fig. 12 | Stem Cell Research & Therapy

Fig. 12

From: Molecular control of nitric oxide synthesis through eNOS and caveolin-1 interaction regulates osteogenic differentiation of adipose-derived stem cells by modulation of Wnt/β-catenin signaling

Fig. 12

Proposed signaling mechanism underlying osteogenic differentiation induced by NO in eASCs. Molecular control of NO levels may activate and suppress the expression of endogenous canonical and non-canonical Wnt ligands, respectively, to promote nuclear localization of β-catenin and subsequent activation of osteogenic differentiation through promoting osteoblast-specific gene transcription. CAV-1 F92A mutated caveolin-1, CAV-1 WT wild-type caveolin-1, eNOS endothelial nitric oxide synthase

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Stem Cell Research & Therapy

ISSN: 1757-6512