Fig. 7

A Effect of MPC treatment on synovial histopathology in the sheep CIA model. Synovial histopathology scores were determined for samples from the left hock joints of control and MPC-treated sheep 14 days after the induction of arthritis. The parameters included stromal cell activation (panel a), intimal hyperplasia (panel b) and inflammatory cell infiltration (panel c), plus a combined total score (panel d). Values were compared between the MPC-treated and the control group using paired Wilcoxon (left and right) and unpaired Mann-Whitney (saline and MPC treatment) tests. Lines represent mean ± SEM of seven to eight sheep. ^* and ^** represent significant difference; p ≤ 0.05 and p ≤ 0.01, respectively. B Representative histopathological images of synovial membranes from arthritic hock joints following saline (a - c) or MPC (d - f) treatment. Paraffin-embedded tissues were stained with haematoxylin and eosin. The bars represent 250 μm. MPC mesenchymal precursor cells