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Table 2 Schematic representation of the groups of mice used in the study

From: The effects of glomerular and tubular renal progenitors and derived extracellular vesicles on recovery from acute kidney injury

  Treatment Doses No. animals Time of sacrifice
  Normal - 5 48 h
- 5 3 weeks
Sham-operated - 5 48 h
IRI-CTL (vehicle) - 8 48 h
- 6 3 weeks
Cells IRI-Gl-MSC 105 cells 8 48 h
105 cells 6 3 weeks
IRI-T-CD133+ 105 cells 8 48 h
105 cells 6 3 weeks
EVs IRI-Gl-MSC-EVs 400 × 106 EVs* 8 48 h
IRI-Gl-MSC-EVs-float 400 × 106 EVs* 6 48 h
IRI-RNase-Gl-MSC-EVs 400 × 106 EVs* 8 48 h
IRI-T-CD133+-EVs 480 × 106 EVs* 8 48 h
IRI-F-EVs 230 × 106 EVs* 5 48 h
  1. IRI ischemia-reperfusion injury, CTL control, Gl-MSC glomerular mesenchymal stromal cells, T-CD133 + -EVs T-CD133+-derived EVs, EVs extracellular vesicles, Gl-MSC-EVs Gl-MSC-derived EVs, Gl-MSC-EVs-float Gl-MSC-derived EVs isolated through floating test, RNase-Gl-MSC-EVs Gl-MSC-derived EVs treated with 5 μg/ml RNase, T-CD133 + CD133+ renal tubular cells, F-EVs fibroblast-derived EVs. *The doses of EVs used were selected as the number of EVs produced overnight by 105 cells in serum starvation