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Table 2 Studies that have evaluated the association between BMI and human ADSC and adipocyte functionality (ordered by sample size)

From: Systematic review of patient factors affecting adipose stem cell viability and function: implications for regenerative therapy

Reference LOE Sample size (n) Subjects Female (n or %) BMI (kg/m2) BMI: subset categories (n) Outcome: ADSC yield Outcome: differentiation potential
Van Harmelan et al. 2003 [34] 2 189 Healthy women undergoing breast reduction procedure 100% 19.7–39.7 <25 kg/m2 (57) 25–29.9 kg/m2 (96) > 30 kg/m2 (35) Significant positive association between BMI and ADSC count per body Significant negative correlation between BMI and ADSC per gram of adipose tissue Significant negative correlation between BMI and ADSC differentiation potential
Faustini et al. 2010 [29] 2 125 Men had more resected samples; women had more lipoaspirates. Donor sites also varied with gender. Therefore, analyses were stratified for gender 88 25.33 ± 3.44 (M) 26.68 ± 5.4 (F) - No significant correlation between ADSC yield and BMI in both males and females -
Yu et al. 2010 [36] 2 64 Elective liposuction surgery or abdominoplasty 90.6% 18.3–37.2 (27.0 ± 3.8) <25 kg/m2 (6) 25–29.9 kg/m2 (6) > 30 kg/m2 (6) Donor BMI was associated with increased ADSC yield per unit volume of lipoaspirate tissue No significant difference in ADSC proliferation in subset analyses (n = 6 each cohort)
Harris et al. 2010 [30] 2 50 Lipoaspirate from abdomen in patients undergoing elective vascular procedures. Multiple co-morbidities 36%   <30 kg/m2 (30) ≥ 30 kg/m2 (20) No significant correlation between ADSC yield and BMI -
Isakson et al. 2009 [49] 2 51 Abdominal subcutaneous tissue: needle biopsy (45) and bariatric surgery (6) - 19.3–54.8 (28.8 ± 2.2) - - Significant negative correlation between BMI and adipogenic differentiation potential
Mojallal et al. 2011 [31] 2 42 Elective liposuction—abdomen 100% 20–35.6 (26.3) ≤25 kg/m2 (15) > 25 kg/m2 (27) No significant correlation between BMI and ADSC yield Tendency toward negative correlation between BMI and proliferation rate (not statistically significant)
Padoin et al. 2008 [32] 2 25 Elective liposuction—multiple donor sites 100% 20–37 (26.2 ± 4.4) - No significant correlation between BMI and ADSC yield (adjusted for donor site) -
Geissler et al. 2014 [27] 2 24 Elective liposuction—multiple donor sites 100% 20.4–34.5 <25 kg/m2 (13) ≥ 25 kg/m2 (11) No significant correlation between BMI and ADSC yield (adjusted for donor site) -
Aust et al. 2004 [28] 2 18 Elective liposuction—hips and thighs 87.5% 20.5–29.3 (24.9 ± 2.7) - Significant negative correlation between BMI and ADSC yield -
Roldan et al. 2011 [52] 2 16 Omental adipose tissue: 12 obese patients undergoing bariatric study and 4 lean patients undergoing abdominal surgery 50% - ≤25 kg/m2 (4) 40–55 (6) ≥ 55 (6) - Significant negative correlation between BMI and ADSC proliferation Positive correlation between BMI, premature senescence and cytokine secretion
Frazier et al. 2013 [48] 2 12 Cryopreserved ASCs isolated from lipoaspirate from abdomen 100% 22.2 ± 1.79 ≤25 kg/m2 (6) > 25 kg/m2 (6) - Significant negative correlation between BMI ADSC proliferation and osteogenic differentiation potential
Perez et al. 2013 [50] 2 10 Adipose tissue from patients after bariatric surgery 100% 20.0 ± 2.1 (<25 kg/m2) 34.0 ± 3.1(>30 kg/m2) <25 kg/m2 (5) > 30 kg/m2 (5) - Significant negative correlation between BMI and ADSC differentiation and migration capabilities
Perez et al. 2015 [51] 2 10 Adipose tissue from patients after bariatric surgery 100% - <22 kg/m2 (5) > 30 kg/m2 (5) Significant negative correlation between BMI and ADSC yield Significant negative correlation between BMI and ADSC proliferation
Significant changes seen in telomerase activity and DNA telomere length leading to reduced self-renewal capacity
Yoshimura et al. 2006 [35] 2 -   100% -   No significant correlation between ADSC yield and BMI -
  1. ADSC adipocyte derived stem cell, BMI body mass index, F female, LOE Level of Evidence, n number