Table 2 Studies that have evaluated the association between BMI and human ADSC and adipocyte functionality (ordered by sample size)

Van Harmelan et al. 2003 [34]

2

189

Healthy women undergoing breast reduction procedure

100%

19.7–39.7

<25 kg/m² (57) 25–29.9 kg/m² (96) > 30 kg/m² (35)

Significant positive association between BMI and ADSC count per body Significant negative correlation between BMI and ADSC per gram of adipose tissue

Significant negative correlation between BMI and ADSC differentiation potential

Faustini et al. 2010 [29]

2

125

Men had more resected samples; women had more lipoaspirates. Donor sites also varied with gender. Therefore, analyses were stratified for gender

88

25.33 ± 3.44 (M) 26.68 ± 5.4 (F)

-

No significant correlation between ADSC yield and BMI in both males and females

-

Yu et al. 2010 [36]

2

64

Elective liposuction surgery or abdominoplasty

90.6%

18.3–37.2 (27.0 ± 3.8)

<25 kg/m² (6) 25–29.9 kg/m² (6) > 30 kg/m² (6)

Donor BMI was associated with increased ADSC yield per unit volume of lipoaspirate tissue

No significant difference in ADSC proliferation in subset analyses (n = 6 each cohort)

Harris et al. 2010 [30]

2

50

Lipoaspirate from abdomen in patients undergoing elective vascular procedures. Multiple co-morbidities

36%

<30 kg/m² (30) ≥ 30 kg/m² (20)

No significant correlation between ADSC yield and BMI

-

Isakson et al. 2009 [49]

2

51

Abdominal subcutaneous tissue: needle biopsy (45) and bariatric surgery (6)

-

19.3–54.8 (28.8 ± 2.2)

-

-

Significant negative correlation between BMI and adipogenic differentiation potential

Mojallal et al. 2011 [31]

2

42

Elective liposuction—abdomen

100%

20–35.6 (26.3)

≤25 kg/m² (15) > 25 kg/m² (27)

No significant correlation between BMI and ADSC yield

Tendency toward negative correlation between BMI and proliferation rate (not statistically significant)

Padoin et al. 2008 [32]

2

25

Elective liposuction—multiple donor sites

100%

20–37 (26.2 ± 4.4)

-

No significant correlation between BMI and ADSC yield (adjusted for donor site)

-

Geissler et al. 2014 [27]

2

24

Elective liposuction—multiple donor sites

100%

20.4–34.5

<25 kg/m2 (13) ≥ 25 kg/m2 (11)

No significant correlation between BMI and ADSC yield (adjusted for donor site)

-

Aust et al. 2004 [28]

2

18

Elective liposuction—hips and thighs

87.5%

20.5–29.3 (24.9 ± 2.7)

-

Significant negative correlation between BMI and ADSC yield

-

Roldan et al. 2011 [52]

2

16

Omental adipose tissue: 12 obese patients undergoing bariatric study and 4 lean patients undergoing abdominal surgery

50%

-

≤25 kg/m² (4) 40–55 (6) ≥ 55 (6)

-

Significant negative correlation between BMI and ADSC proliferation Positive correlation between BMI, premature senescence and cytokine secretion

Frazier et al. 2013 [48]

2

12

Cryopreserved ASCs isolated from lipoaspirate from abdomen

100%

22.2 ± 1.79

≤25 kg/m² (6) > 25 kg/m² (6)

-

Significant negative correlation between BMI ADSC proliferation and osteogenic differentiation potential

Perez et al. 2013 [50]

2

10

Adipose tissue from patients after bariatric surgery

100%

20.0 ± 2.1 (<25 kg/m²) 34.0 ± 3.1(>30 kg/m²)

<25 kg/m² (5) > 30 kg/m² (5)

-

Significant negative correlation between BMI and ADSC differentiation and migration capabilities

Perez et al. 2015 [51]

2

10

Adipose tissue from patients after bariatric surgery

100%

-

<22 kg/m² (5) > 30 kg/m² (5)

Significant negative correlation between BMI and ADSC yield

Significant negative correlation between BMI and ADSC proliferation

Significant changes seen in telomerase activity and DNA telomere length leading to reduced self-renewal capacity

Yoshimura et al. 2006 [35]

2

-

100%

-

No significant correlation between ADSC yield and BMI

-