Fig. 6
Model of prion protein (PrP) as a scaffold protein modulating GSC biology. Scheme illustrating how PrPC may act as a scaffold protein, regulating stemness (dowregulation of CD133 and Sox2 and Msi1 sub-localization altered), recruiting cell adhesion molecules (E-cadherin and integrin α6β1), binding CD133-β-catenin to the plasma membrane, and modulating GSC proliferation and self-renewal through its interaction with Hsp70/90 organizing protein (HOP). Blockage of PrPC-HOP interaction with HOP peptide impairs the binding of HOP and PrPC and, consequently, Erk1/2 activation, affecting proliferation