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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Impaired osteogenesis of T1DM bone marrow-derived stromal cells and periosteum-derived cells and their differential in-vitro responses to growth factor rescue

Fig. 5

rhBMP-2/7 treatment (300 ng/ml) upregulates osteogenic gene expression and suppresses adipogenic gene expression in diabetic PDCs, but not in diabetic BMSCs, in high glucose (25 mM) osteogenic cultures. Relative Col1, OCN, GLUT1, and PPARγ expressions (n = 3) in a diabetic PDCs and b diabetic BMSCs in high glucose osteogenic cultures with rhBMP2/7 treatment are reported relative to that of the respective cultures without BMP-2/7 treatment (set to 1). *p < 0.05 (Student’s t test) for pairwise comparisons between cultures with and without growth factor rescue for a given cell type; error bars, standard deviation of the mean. BMP-2/7 bone morphogenetic protein-2/7 heterodimer, BMSC bone marrow-derived stromal cell, PDC periosteum-derived cell, Col 1 type 1 collagen, GLUT1 glucose transporter 1, PPARγ peroxisome proliferator-activated receptor gamma, OCN osteocalcin

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Stem Cell Research & Therapy

ISSN: 1757-6512