Fig. 6

CD99 is a negative regulator of autophagy in MSCs. a CD99 recombinant protein had no influence on cell morphology after 3 days in culture but induced proliferation of MSCs. b Cell cycle analysis is shown. Means with SEM of three experiments are shown. ^** P <0.05, Student’s t test. c Autophagy machinery – p53, p21, and LC3 – was suppressed in a dose-dependent manner by introduction of CD99 recombinant protein (WB analysis)