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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Distribution pattern following systemic mesenchymal stem cell injection depends on the age of the recipient and neuronal health

Fig. 2

Migration of transplanted MSCs into the brain of APP/PS1 mice. Intravenously transplanted GFP + MSCs were able to migrate into the brain parenchyma. GFP+ MSCs (green, centre panel) were found in association with activated microglia (Iba-1; red, left panel), but only partly showing overlap with Iba-1 immunoreactivity (right panel). In the merged image (orthoview based on stack analysis), Iba-1 and GFP are shown in combination with nuclei (DAPI, blue) and, in addition to the X–Y image, orthogonal X–Z and Y–Z projections are shown. Scale bar: 20 μM (Colour figure online)

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Stem Cell Research & Therapy

ISSN: 1757-6512