Fig. 2
Gross morphological changes in the distal colon assessed in H&E-stained cross sections. A complete and continuous epithelial lining (black arrows) and regular arrangement of colonic layers was apparent in sections from sham-treated animals (a). Flattening of the glands, disruption to the epithelial lining (dotted black arrows) and goblet cell loss were evident in sections from TNBS-administered guinea-pigs at 72 hours post induction of colitis (b). H&E-stained sections from 1 × 105, 1 × 106 and 3 × 106 MSC-treated animals revealed accelerated repair and restoration of the colonic architecture (c-e). Scale bars = 50 μm, n = 4/group/time point. MSCs mesenchymal stem cells, TNBS 2,4,6-trinitrobenzene sulfonic acid