Fig. 4

Quantitative analysis of label-retaining cell (LRC) distribution in the adult prostate. Quantification of LRCs in the adult mouse prostate showed that epithelial LRCs were significantly more numerous in prostatic ducts (green) (3.7 ± 0.47%, mean ± SD) as compared to both proximal (blue) and distal (red) lobular epithelium, and that proximal epithelium contained significantly more LRCs than distal epithelium (1.40 ± 0.83% vs. 0.48 ± 0.08%). Importantly, both basal and luminal LRCs were detected in the secretory epithelium and ducts of the adult prostate. Basal LRCs in the adult prostate varied significantly between ducts and proximal epithelium (7.89 ± 0.97% vs. 2.64 ± 0.81%, p < 0.01), and between proximal and distal secretory epithelium (2.64 ± 0.81 vs. 1.17 ± 0.42%, p < 0.01). Likewise, luminal LRCs varied significantly between ducts and proximal/distal epithelium (1.82 ± 0.31% vs. 0.22 ± 0.04%, p < 0.01; and 1.82 ± 0.31% vs. 0.15 ± 0.02%, p < 0.01), but not significantly between proximal and distal epithelium. Error bars represent standard deviation (SD). **p ≤ 0.01