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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: The crosstalk between vascular MSCs and inflammatory mediators determines the pro-calcific remodelling of human atherosclerotic aneurysm

Fig. 6

Low expression of CD146 in AAA-MSC newly formed vessels. a Flow cytometry analysis of CD31 and CD146 proteins in ha-MSC and AAA-MSC 2D culture before seeding in Matrigel. b Gene expression profiles of angiogenic markers CD31, α-SMA and CD146 in healthy and AAA-MSCs after Matrigel culture for 6 hours. Results are expressed as fold changes relative to ha-MSC control; statistical analysis performed by two-way ANOVA with multiple comparisons among all experimental conditions. *p < 0.05, ***p < 0.001. c CD146 protein expression in ha-MSC and AAA-MSC newly formed vessels, as detected by flow cytometry after Matrigel dissociation. a, c Black histograms, untreated ctrl; white histograms, VEGF-induced condition. ha-MSC healthy aortic MSC, AAA-MSC abdominal aortic aneurysm MSC, MSC mesenchymal stem cell, ctrl control, VEGF vascular endothelial growth factor

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