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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Differential expression of cell cycle and WNT pathway-related genes accounts for differences in the growth and differentiation potential of Wharton’s jelly and bone marrow-derived mesenchymal stem cells

Fig. 5

Relative expression of genes related to WNT pathway in WJ-MSCs and BM MSCs. a The columns represent the mean fold change of genes involved in WNT signaling in P2 WJ-MSCs (n = 6) as compared to BM–MSCs (n = 6) using a real-time PCR array. Only genes exhibiting at least a two-fold change in their expression are depicted. b Validation of the array. The bars represent the relative mRNA expression (mean + 1 standard deviation) of WISP1 and sFRP4 in WJ-MSCs (n = 18) and BM-MSCs (n = 18) at P2 using real-time RT-PCR. Values correspond to 2−ΔCt using GAPDH as control gene. Comparisons between WJ- and BM-MSCs were performed by the nonparametric Mann-Whitney U test and the P values are depicted. Abbreviations: BM-MSCs bone marrow-mesenchymal stem cells, sFRP4 secreted frizzled related protein 4, WISP1 WNT1-inducible-signaling pathway protein 1, WJ-MSCs Wharton’s jelly-mesenchymal stem cells

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Stem Cell Research & Therapy

ISSN: 1757-6512