Skip to main content
Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: ERK signaling is required for VEGF-A/VEGFR2-induced differentiation of porcine adipose-derived mesenchymal stem cells into endothelial cells

Fig. 7

Signaling transduction pathway of AMSC differentiation to ECs and negative crosstalk between ERK and JNK. ERK receives signals from VEGFR2, and induces the transcription of EC markers during AMSC stimulation for EC differentiation. ERK activation phosphorylates MKP-7 and blocks the JNK signaling pathway. ERK extracellular signal-regulated kinase, VEGF vascular endothelial growth factor, VEGFR2 vascular endothelial growth factor receptor-2, JNK c-Jun NH2-terminal kinase, MKP-7 MAP kinase phosphatase-7, EC endothelial cell

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512