Fig. 1

Effect of ADHLSCs on HSC culture. a Morphology of HSCs recovered after 24 h of co-culture without ADHLSCs (A1) or with ADHLSCs at an ADHLSC:HSC ratio of 1:100 (A2). b Significant decrease in the number of adherent HSCs after 24 h of co-culture at an ADHLSC:HSC ratio of 1:100, which was maintained for up to 7 days (N = 6 for 24 h; N = 4 for 4 and 7 days). c Significant decrease in the number of HSCs after 24 h of co-culture at an ADHLSC:HSC ratio of 1:100, using the CCK-8 biochemical assay (N = 4). Results are expressed as mean ± standard error of the mean (SEM). ^*** p value < 0.001; ^** p < 0.01; ^* p < 0.05. ADHLSCs adult-derived human liver mesenchymal stem/progenitor cells, HSC hepatic stellate cells