Fig 3

Tooth–periodontium complex structures formed from mES cells. a Experimental schematic diagram. b Tooth-like structures under the renal capsule. c Tooth-like structures under a stereoscopic microscope. d Tooth-like structures under micro-CT. Results showed it contained three different teeth types and periodontal tissue. e Intensity of the enamel and dentine were higher than normal mouse teeth. f HE staining showed tooth-like structures containing dental pulp (DP), dentin (D), enamel space (ES), alveolar bone (AB), periodontal membrane (PM), and dental cement (DC). E embryonic day