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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Human adipose tissue mesenchymal stromal cells and their extracellular vesicles act differentially on lung mechanics and inflammation in experimental allergic asthma

Fig. 4

Representative photomicrographs of lung parenchyma (upper panels) and airway (lower panels) stained with Sirius Red under polarization. Percentage of collagen fiber content in lung parenchyma and airway. Levels of transforming growth factor beta (TGF-β) in lung tissue. Data are presented as means + SD of seven animals/group. CTRL mice sensitized and challenged with saline, OVA mice sensitized and challenged with ovalbumin, OVA-SAL OVA mice treated with saline, OVA-AD-MSC OVA mice treated with mesenchymal stromal cells derived from adipose tissue (AD-MSCs), OVA-EV OVA mice treated with extracellular vesicles derived from AD-MSCs. CTRL versus OVA-SAL (parenchyma p < 0.0001, airway p = 0.0002, TGF-β p = 0.0007)

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Stem Cell Research & Therapy

ISSN: 1757-6512