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Table 1 Comparison between human adipose-derived mesenchymal stromal cells (AD-MSC) with extracellular vesicles (EV) in OVA-induced allergic asthma model

From: Human adipose tissue mesenchymal stromal cells and their extracellular vesicles act differentially on lung mechanics and inflammation in experimental allergic asthma

Parameters AD-MSC EV
Reduction of static lung elastance
Reduction of collagen fiber content in lung parenchyma and airway
Reduction of eosinophils in in lung parenchyma
Reduction of T lymphocytes in BALF
Increase of Treg cells in BALF
Reduction of eosinophils in BALF
Reduction of TGF-β in lung tissue
Reduction of eotaxin in lung tissue
Reduction of IL-5 in lung tissue
Reduction of IL-4 in lung tissue
Reduction of IL-13 in lung tissue
  1. X means inability to promote parameter improvement and means ability to promote the parameter improvement
  2. BALF bronchoalveolar lavage fluid, Treg regulatory T cells, TGF transforming growth factor, IL interleukin