Human adipose tissue mesenchymal stromal cells and their extracellular vesicles act differentially on lung mechanics and inflammation in experimental allergic asthma

Table 1 Comparison between human adipose-derived mesenchymal stromal cells (AD-MSC) with extracellular vesicles (EV) in OVA-induced allergic asthma model

Parameters	AD-MSC	EV
Reduction of static lung elastance	✕	✓
Reduction of collagen fiber content in lung parenchyma and airway	✓	✓
Reduction of eosinophils in in lung parenchyma	✕	✓
Reduction of T lymphocytes in BALF	✕	✓
Increase of Treg cells in BALF	✕	✕
Reduction of eosinophils in BALF	✓	✓
Reduction of TGF-β in lung tissue	✓	✓
Reduction of eotaxin in lung tissue	✓	✓
Reduction of IL-5 in lung tissue	✓	✓
Reduction of IL-4 in lung tissue	✕	✓
Reduction of IL-13 in lung tissue	✓	✕

X means inability to promote parameter improvement and ✓ means ability to promote the parameter improvement
BALF bronchoalveolar lavage fluid, Treg regulatory T cells, TGF transforming growth factor, IL interleukin

ISSN: 1757-6512