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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Inhibitory effects of HNF4α on migration/maltransformation of hepatic progenitors: HNF4α-overexpressing hepatic progenitors for liver repopulation

Fig. 5

HNF4α was a key transcription factor for hepatic oval cells engrafting and repopulating CCl4-injured NOD/SCID mouse liver. a Experimental design of transplanting control, HNF4α-overexpressing, or HNF4α-suppressing rat hepatic oval cells into CCl4-injured NOD/SCID mice by tail vein injection. b Immunofluorescence data revealed that few ALB-positive cells could be detected in HNF4α-suppressing hepatic oval cell-transplanted mice, while ALB and GFP double-positive cells could be detected in the mice transplanted with control and HNF4α-overexpressing hepatic oval cells. Hepatocytes derived from HNF4α-overexpressing oval cells were located around the portal vein, while hepatocytes derived from control oval cells migrated into the recipient liver parenchyma. ALB albumin, CCl 4 carbon chloride, HNF hepatic nuclear factor (Color figure online)

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Stem Cell Research & Therapy

ISSN: 1757-6512