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Table 1 Effect of mesenchymal stem cells on wild-type and CXCR3–/– fibroblast expression of genes encoding extracellular matrix molecules

From: Multipotent stromal cells/mesenchymal stem cells and fibroblasts combine to minimize skin hypertrophic scarring

Gene symbol

GenBankâ„¢ accession number

Common name

Fold change + MSC/control (WT)

p value

Fold change + MSC/control (KO)

p value

Fn1

NC_000067

Fibronectin 1

1.91

0.0524

3.21

0.0317

Tnc

NC_000070

Tenascin C

1.33

0.0989

2.36

0.0497

Lama1

NC_000083

Laminin, alpha 1

0.89

0.5424

1.34

0.0605

Col3a1

NC_000067

Procollagen, type III, alpha 1

2.67

0.04

2.85

0.035

Actg2

NC_000072

Actin, gamma 2, smooth muscle, enteric

0.25

0.1732

1.77

0.0739

Col4a3

NC_000067

Procollagen, type IV, alpha 3

2.63

0.0352

3.09

0.0204

Mmp9

NC_000068

Matrix metallopeptidase 9

2.41

0.0052

0.88

0.605

Tgfb-1

NC_000073

Transforming growth factor beta-1

0.64

0.1862

0.7

0.1773

Gapdh

NC_000072

Glyceraldehyde-3-phosphate dehydrogenase

1.6

0.0089

1.98

0.0056

  1. RNA was extracted from dermal fibroblasts cocultured with MSCs for 36 hours. Gene expression levels were measured. Fold changes in mRNA levels were determined by dividing gene expression levels of fibroblasts cocultured with mesenchymal stem cells by gene expression levels of fibroblasts cocultured with control inserts. Genes in the table demonstrated consistent and statistically significant fold changes (p < 0.05) in response to MSCs. All changes in mRNA levels were statistically significant and reproduced in three independent experiments
  2. KO knock out, MSC mesenchymal stem cell, WT wild type
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Stem Cell Research & Therapy

ISSN: 1757-6512