Fig. 6

Knockdown of SAMSN1 may attenuate differentiation and/or function of KLCs in ADPKD. (a–c) Morphology of TSG control induced cells and TSG SAMSN1-induced iPSCs and the relative expression rates of SAMSN1 in TSG SAMSN1-induced iPSCs compared to those in TSG control-induced cells. Bar = 100 μm. Data presented as mean ± standard deviation from three independent sets of experiments, **P < 0.01. (d–f) BSA absorption assays of TSG control-induced cells and TSG SAMSN1-induced iPSCs. Bar = 25 μm. Data presented as mean ± standard deviation from three independent sets of experiments, **P < 0.01. (g) Results of water transportation assays of TSG control-induced cells and TSG SAMSN1-induced iPSCs. Data presented as mean ± standard deviation from three independent sets of experiments, *P < 0.05, **P < 0.01. ADPKD autosomal dominant polycystic kidney disease, iPSC induced pluripotent stem cell, TSG name of family member (Color figure online)