Skip to main content
Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: pIL6-TRAIL-engineered umbilical cord mesenchymal/stromal stem cells are highly cytotoxic for myeloma cells both in vitro and in vivo

Fig. 1

Structure of pMIGR1 vector and steps for UC-MSC transduction. a Structural construction of the bicistronic retroviral vector including both TRAIL and GFP sequences controlled by the IL-6 promoter. PIRES sequence was inserted to codify two different proteins from a single mRNA. b Sequential phases of multiple cell transfection, viral particle enrichment, and final transduction of UC-MSCs. GFP green fluorescent protein, MSC mesenchymal/stromal stem cell, pIL6 interleukin-6 promoter, PIRES poliovirus internal ribosome entry site, TRAIL tumor necrosis factor related apoptosis inducing ligand, UC umbilical cord

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512