Fig. 3
Application of haESCs in multiple types of genetic screening. Since haESCs contain a haploid copy of the genome, it is easy to obtain homozygous mutant libraries through transposon or viral systems. To date, mutant haESC libraries have been exploited in various targeted gene screening systems in order to track cell fate. Such systems include factors such as toxic resistance [4, 5], cell differentiation [6, 37, 48], and X-chromosome inactivation [7, 35, 36]. haESC haploid embryonic stem cell