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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Human umbilical cord-derived mesenchymal stem cells ameliorate insulin resistance by suppressing NLRP3 inflammasome-mediated inflammation in type 2 diabetes rats

Fig. 7

UC-MSCs attenuated HFD/STZ-induced insulin resistance and inflammation in the liver. (a) Gene expression of molecules involved in the inflammation of liver; results presented relative to the control WT rats. (b) Levels of IL-1β, IL-18, and TNF-α in the liver of all rat groups. (c) Immunoblotting analysis of liver in control WT rats, T2D rats, or MSC-treated rats. Relative protein levels of NLRP3, p-IRS, PI3K, p-AKT, and Glut4 are shown. *P < 0.05, **P < 0.01, ***P < 0.001. DM diabetes mellitus, IL interleukin, TNF tumor necrosis factor, UC-MSC umbilical cord-derived mesenchymal stem cell

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Stem Cell Research & Therapy

ISSN: 1757-6512