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Table 1 Characteristics of studies included in the meta-analysis

From: Effects of timing on intracoronary autologous bone marrow-derived cell transplantation in acute myocardial infarction: a meta-analysis of randomized controlled trials

Source

Sample size

Male (%)

Age (year)

Primary intervention and route of delivery

Cell type

Cell dose

Time of cell therapy

Follow-up (months)

Measure tools

Baseline LVEF (%)

Janssens 2006 [11]

67

82

56.9

PCI IC

BMSC

304 × 10^6

Within 1 day after PCI

4

MRI

48.1

Yousef 2009 [12]

62

89.6

51.1

PCI IC

BMC

6.1 (3.9) × 10^7

Mean 7 days after PCI

60

Echo

51.2

Wang 2014 [13]

58

60.6

57

PCI IC

BMSC

1 × 10^8

Mean 15 days after PCI

6

Echo

29

Piepoli 2010 [14]

38

68.4

65

PCI IC

BMC

418 × 10^6

3 to 5 days after PCI

12

Echo

37.1

Panovsky (HD) 2008 [15]

47

89.3

54

PCI IC

BMC

1 × 10^8

Mean 7 days after PCI

3

SPECT

35

Panovsky (LD) 2008 [15]

47

89.3

54

PCI IC

BMC

1 × 10^7

Mean 7 days after PCI

3

SPECT

35.5

Gao 2013 [16]

54

93.2

56.8

PCI IC

BMSC

3.08 (0.52) × 10^6

Mean 17 days after PCI

12

SPECT,Echo

51.1

Sürder (day 6) 2016 [17]

150

84.1

57.7

PCI IC

BMSC

1.40 × 10^8

Mean 6 days after PCI

12

MRI

37.1

Sürder (day 24) 2016 [17]

150

84.1

57.7

PCI IC

BMSC

1.60 × 10^8

Mean 24 days after PCI

12

MRI

37.6

Traverse 2011 [18]

87

82.8

56.1

PCI IC

BMC

150 × 10^6

2 to 3 weeks after PCI

6

MRI

47

Plewka 2009 [19]

60

73

56

PCI IC

BMSC

1.44 (0.49) × 10^8

Mean 7 days after PCI

6

Echo

39.5

Traverse (day 3) 2012 [20]

67

88

56.3

PCI IC

BMC

150 × 10^6

3 days after PCI

6

MRI

43.9

Traverse (day 7) 2012 [20]

53

87.2

57.6

PCI IC

BMC

150 × 10^6

7 days after PCI

6

MRI

46.4

Chen 2004 [21]

69

95.5

57.5

PCI IC

BMSC

8 × 10^9

Nearly 18 days after PCI

6

SPECT

48.5

Ge 2006 [22]

20

90

58.5

PCI IC

BM-MNC

4 × 10^7

Within 1 day after PCI

6

SPECT,Echo

56

Wöhrle 2013 [23]

42

-

-

PCI IC

BMC

324 × 10^6

Mean 7 days after PCI

36

CMR

54.6

Herbots 2009 [24]

67

82.1

56.5

PCI IC

BMPC

304 (128) × 10^6

Within 1 day after PCI

4

MRI

54.4

Grajek 2010 [25]

45

86.7

50.4

PCI IC

BMSC

2.34 (1.2) × 10^9

4 to 6 days after PCI

12

Echo

50.6

Dill 2009 [26]

54

90.7

56.3

PCI IC

BMC

236 (174) × 10^6

3 to 6 days after PCI

12

CMR

47.8

Wollert 2004 [27]

60

70

56.3

PCI IC

BMC

24.6 × 10^8

4.8 days after PCI

6

MRI

50.7

Roncalli 2011 [28]

101

85.3

55.5

PCI IC

BMC

98.3 (8.7) × 10^6

7 to 10 days after PCI

3

RNA

36.3

Meyer 2009 [29]

60

70

56.3

PCI IC

BMC

24.6 (9.4) × 10^8

Mean 4.8 days after PCI

61

MRI

50.7

Schächinger 2006 [30]

204

82

56

PCI IC

BMC

2.36 (1.74) × 10^8

Within7days after PCI

4

LVangiography

47.6

Bartunek 2005 [31]

35

91

54

PCI IC

BMPC

12.6 (2.2) × 10^6

Mean 11.6 days after PCI

4

SPECT

44.7

Lunde 2006 [32]

100

84

57.4

PCI IC

BMC

68 × 10^6

Mean 6 days after PCI

6

SPECT

42

Beitnes 2011 [33]

100

84

57.4

PCI IC

BM-MNC

68 × 10^6

Mean 6 days after PCI

36

Echo

46.3

Huang 2006 [34]

40

67.5

57

PCI IC

BM-MNC

1.8 (4.2) × 10^8

Within 1 day after PCI

6

CMR

44

Cao 2009 [35]

86

93.2

56.8

PCI IC

BM-MNC

5 (1.2) × 10^7

7 days after PCI

48

Echo

38.8

Hopp 2011 [36]

28

78.5

58.6

PCI IC

BMC

8.71 × 10^7

Mean 6 days after PCI

6

CMR

51.7

Yao 2009 [37]

39

84.6

52

PCI IC

BMC

1.9 (1.2) × 10^8

3 to 7 days after PCI

12

MRI

32.4

Meluzín (HD) 2008 [38]

60

91.7

54.3

PCI IC

BMC

10^8

Mean 7 days after PCI

12

SPECT

40

Meluzín (LD) 2008 [38]

60

91.7

54.3

PCI IC

BMC

10^7

Mean 7 days after PCI

12

SPECT

40.5

Wollert (LD) 2017 [39]

64

87.2

53.8

PCI IC

BMSC

7.00 × 10^8

Mean 8.1 days after PCI

6

MRI

45.7

Wollert (HD) 2017 [39]

59

88.1

56.1

PCI IC

BMSC

20.60 × 10^8

Mean 8.1 days after PCI

6

MRI

45.8

  1. BMC bone marrow-derived cells, BMSCs bone marrow stem cells, BM-MNC bone marrow mononuclear cells, BMPC bone marrow progenitor cell, PCI percutaneous coronary intervention, IC intracoronary, Echo echocardiography, MRI magnetic resonance imaging, SPECT single-photon emission computed tomography, LVEF left ventricular ejection fraction