From: miRNA profiling of NurOwn®: mesenchymal stem cells secreting neurotrophic factors
miRNA ID | Microarray fold change (MSC-NTF vs MSC) | Function | qPCR validated (p ≤ 0.05) | Fold change (MSC-NTF vs MSC) |
---|---|---|---|---|
hsa-miR-503-5p | −8.38 | Anti-angiogenic [17, 25] Promotes osteogenesis [26] (Originates from the same primary RNA transcript as miR-424 [27] | Yes | −30.5 |
hsa-miR-320b | −2.41 | Involved in neural development, anti-angiogenic [28] | Yes | −1.36 |
hsa-miR-320a | −1.97 | Targets VEGF A [16] | No | −1.28 |
hsa-miR-222-3p | −1.74 | Negative modulator of angiogenesis Inhibition of osteogenic differentiation [29] | No | −1.25 |
hsa-miR-424-5p | −1.72 | Yes | −1.94 | |
hsa-miR-3663-3p | 8.03 | On/off signal. No validated mRNA target | Yes | 18.5 |
hsa-miR-132-3p | 7.85 | Pro-angiogenic [30] Inhibits osteoblast differentiation [31] Regulation of synaptic structure [18] | Yes | 4.06 |
hsa-miR-150-3p | 6.99 | On/off signal. Inhibits osteoblast differentiation downstream of TNF-α [32] | Not validated but significantly downregulated | −4.44 |
hsa-miR-762 | 5.91 | Upregulated in neural precursors [33] | No | 1.47 |
hsa-miR-34a-5p | 4.05 | Tumor suppressor: pro-apoptotic and anti-proliferative [34] TNF-α suppressor [35] Inhibits osteoblast differentiation [36] | Yes | 3.16 |