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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Human iPSC-derived chondrocytes mimic juvenile chondrocyte function for the dual advantage of increased proliferation and resistance to IL-1β

Fig. 2

Immune resistance in hiChondrocytes and juvenile chondrocytes compared to adult chondrocytes. Upon IL-1β stimulation (10 ng/ml) gene expression of (a) inflammatory genes (IL6 and CCL2), (b) catabolic genes (MMP3 and ADAMTS4), and (c) chondrocyte regulatory genes (COL2A and SOX9) in hiChondrocytes, juvenile chondrocytes, and adult chondrocytes. *p < 0.01. Gene expression relative to control in the absence of IL-1β for each respective gene. Data represent two independent donors for each chondrocyte type and three replicate experiments

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Stem Cell Research & Therapy

ISSN: 1757-6512