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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Poly(ethylene glycol)-modified silk fibroin membrane as a carrier for limbal epithelial stem cell transplantation in a rabbit LSCD model

Fig. 7

Construction of rabbit LSCD model. a Rabbit total LSCD model with removal of the limbus and cornea epithelium. Advanced neovascularization and epithelial defects (fluorescein sodium staining) present on the cornea. Arrows point to the advanced neovascularization and new blood vessels. b OCT of rabbit total LSCD model. Limbal epithelium about 270 μm in depth was removed. c Examples of corneal neovascularization scores (blue numbers) and clarity scores (green numbers). d Averaged neovascularization and corneal clarity scores at 3, 10, 20, and 30 days after surgery in rabbit total LSCD model. Data was shown as mean ± SD from three rabbits. e, f Corneas of total LSCD model exhibited LSCD-characteristic epithelial conjunctivalization (conjunctival epithelial cells marker CK7 staining) and new blood vessels (vascular endothelial cells marker CD31 staining). Scale bar, 500 μm (b), 50 μm (e, f). CK7 cytokeratin7, DAPI 4′,6-diamidino-2-phenylindole

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Stem Cell Research & Therapy

ISSN: 1757-6512