Fig. 1

CAPE increased the survival rate. a BM transplantation and treatment model. All mice were lethally irradiated (950 cGy, 80–120 cGy/min) on day 0. Mice were injected intraperitoneally with 3.0 mg/kg of CAPE at different schedules. Each mouse was transplanted with 2.5 × 10⁵ BM MNCs on day +1. b Survival rates of the lethally irradiated recipients receiving BMT and CAPE injection with different schedules. All mice were administered vehicle or 3.0 mg/kg CAPE intraperitoneally. Vehicle: vehicle daily for 3 days (n = 15); CAPE D0: vehicle on day –1 and day +1, CAPE on day 0 (n = 10); CAPE D–1,D0: CAPE on day –1 and day 0, vehicle on day +1 (n = 10); CAPE D0,D + 1: vehicle on day –1, CAPE on day 0 and day +1 (n = 10); CAPE D–1,D0,D + 1: CAPE daily for 3 days (n = 16). c Survival rate of lethally irradiated mice receiving BMT and CAPE injection at different dosages. Lethally irradiated mice were injected with 0 (Vehicle), 0.3, 1.5 or 3.0 mg/kg CAPE from day –1 to day +1. TBI total body irradiation, BMT bone marrow transplantation, CAPE caffeic acid phenethyl ester