Skip to main content
Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Evaluating the oxysterol combination of 22(S)-hydroxycholesterol and 20(S)-hydroxycholesterol in periodontal regeneration using periodontal ligament stem cells and alveolar bone healing models

Fig. 7

Effect of LXR and Hh signaling on oxysterol-induced PDLSC osteogenesis. Cells pretreated with 22-NHC or transfected with LXRαβ siRNAs before SS (1 μM) treatment. (a) ALP activity. (b) mRNA expression and (c) protein levels of OCN, OSX, and RUNX2. Data obtained from three independent experiments. *P < 0.05 vs control value; # P < 0.05 vs SS treatment alone. LXR liver X receptor, NC negative control, 22-NHC 22-azacholesterol, OCN osteocalcin, OSX osterix, RUNX2 Runt-related transcription factor 2, siRNA small interfering RNA, SS 22(S)-hydroxycholesterol and 20(S)-hydroxycholesterol

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512