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Table 5 Experimental studies testing the efficacy of MSC-derived EVs in UUO-CKD

From: Mesenchymal stem cell-derived extracellular vesicles for kidney repair: current status and looming challenges

Type of model Species Intervention Administration methods Main findings Reference
In vivo; in vitro, tubular epithelial cells Mouse Allogenic bone marrow MSC-derived EVs Intravenous • EVs preserved renal function
• Decreased tubular injury and epithelial to mesenchymal transition
He et al. 2015 [57]
In vivo; in vitro; human umbilical vein endothelial cells Mouse Allogenic kidney MSC-derived EVs Intravenous • EVs ameliorated endothelial to mesenchymal transition and improved proliferation
• Prevented inflammatory cell infiltration, enhanced proliferation of tubular cells, and decreased apoptosis and microvascular rarefaction
Choi et al. 2015 [58]
  1. CKD chronic kidney disease, EV extracellular vesicle, MSC mesenchymal stem cell, UUO unilateral ureteral obstruction