Fig. 6

Effect of EFS on liver regeneration and recovery in ischemic/reperfusion model of liver failure. Liver regeneration rate of untreated rodent model (defect), model treated with unfractionated MSC secretome (defect + MSC-CM) and model treated with fractionated MSC secretome (defect + EFS). Statistical analysis: n = 3 (control); n = 5 (models), *p < 0.05, **p < 0.01 (a). AST (b), ALT (c), bilirubin (d) and albumin (e) levels in untreated liver failure models (PHx), models treated with unfractionated secretome (PHx + MSC-CM) and models treated with fractionated secretome (PHx + EFS). Statistical analysis: n = 3, *p < 0.05, **p < 0.01, #ns. MSC mesenchymal stromal cell, CM conditioned medium, EFS exosome-rich fractionated secretome, AST aspartate transaminase, ALT alanine transaminase, PHx partial hepatectomy