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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Targeting ectodysplasin promotor by CRISPR/dCas9-effector effectively induces the reprogramming of human bone marrow-derived mesenchymal stem cells into sweat gland-like cells

Fig. 5

The effect of Dox-induced dCas9-E BM-MSCs on wound healing in vivo. a The mice were treated with Dox-induced dCas9-E BM-MSCs after full thickness scald injuries. b Sirius Red staining and Masson staining were used to detect the fibrosis, and the arrangement of collagen fibers was more regular than in the sham-treated group. Immunostaining was performed for c Ki67 (green) and d CD31 (red) after treatment with Dox-induced dCas9-E BM-MSCs. Scale bars = 20 μm. DAPI 4’6-diamidino-2-phenylindole, sgRNA single-guide RNA

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Stem Cell Research & Therapy

ISSN: 1757-6512