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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Human amniotic mesenchymal stem cells improve ovarian function in natural aging through secreting hepatocyte growth factor and epidermal growth factor

Fig. 3

Human amniotic mesenchymal stem cells (hAMSCs) improve the proliferation rate of human granulosa cells (hGCs) and upregulate the expression of hGC markers. a A schematic overview of the hGC filter procedures. b The number of ki67+AMH+ hGCs was evaluated after a co-culture with hAMSCs. c The expression level of the ki67+FSHR+ hGCs was tested after a co-culture with hAMSCs. d The expression level of the ki67+FOXL2+ hGCs was tested after a co-culture with hAMSCs. e The number of ki67+CYP19A1+ hGCs was evaluated after a co-culture with hAMSCs. The experiments were carried out after 7 days of co-culture, n = 3; error bars indicate SD. **p < 0.01, ***p < 0.001, versus the NOA group. AMH anti-mullerian hormone, FOXL2 forkhead box L2, FSHR follicle-stimulating hormone receptor, NOA natural ovarian aging, PBS phosphate-buffered saline

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Stem Cell Research & Therapy

ISSN: 1757-6512