Fig. 4

Improvement in hormone levels after placental CP-MSC transplantation. A significant improvement in the hormone level was observed in premature ovarian failure (POF) after the administration of placental chorionic plate-derived mesenchymal stem cells (CP-MSCs) (P < 0.05, CP-MSC treatment group versus the POF model group). The administration of saline to the POF mouse model improved the hormone level slightly; however, this change was not significant (P > 0.05, saline treatment group versus POF model group). The levels of estradiol (E2) and follicle-stimulating hormone (FSH) in the serum was assayed at 2, 4, and 6 weeks post-transplantation of CP-MSCs. The hormone concentration of wild-type (WT) and POF model groups were maintained at a stable level (P < 0.05, POF model group versus WT group). WT: wild-type mouse without any treatment as a blank control group; CP-MSCs: POF mouse model treated with CP-MSCs as an experimental group; POF: POF mouse model without any treatment as a negative control group; Saline: POF mouse model treated with saline as a vehicle group