Table 2 Univariate and multivariate Cox regression analysis for lung adenocarcinoma in validated datasets

 Gender (male/female)

1.484

0.651–3.387

0.348

 Stage (≥ II/I)

3.107

1.358–7.110

0.007

2.971

1.295–6.819

0.010

 Age (≥ 65/< 65 years)

1.854

0.813–4.231

0.142

 Smoking (yes/No)

2.101

0.907–4.867

0.083

 TBX21 (high risk/low risk)

4.550

1.960–10.560

0.000

1.018

1.002–1.035

0.028

 Gender (male/female)

1.111

0.464–2.661

0.813

 Stage (≥ II/I)

1.669

0.878–3.173

0.118

 Age (≥ 65/< 65 years)

2.539

1.250–5.158

0.010

2.267

1.108–4.637

0.025

 TBX21 (high risk/low risk)

2.876

1.457–5.677

0.002

2.625

1.284–5.365

0.008

 Gender (male/female)

1.376

1.008–1.878

0.044

1.425

1.033–1.965

0.031

 Stage (≥ II/I)

1.713

1.362–2.153

0.000

1.621

1.272–2.066

0.000

 Age (≥ 65/< 65 years)

1.266

0.928–1.726

0.137

 Smoking (yes/no)

1.045

0.626–1.744

0.866

 TBX21 (high risk/low risk)

2.147

1.561–2.952

0.000

1.009

1.007–1.012

0.000

 Gender (male/female)

1.500

0.976–2.305

0.065

 Stage (≥ II/I)

2.593

1.676–4.011

0.000

2.682

1.734–4.149

0.000

 Age (≥ 65/< 65 years)

1.485

0.882–2.501

0.137

 Smoking (yes/no)

1.966

0.714–5.413

0.191

 TBX21 (high risk/low risk)

1.424

1.091–1.859

0.009

1.469

1.127–1.914

0.004

 Gender (male/female)

0.943

0.601–1.480

0.798

 Stage (≥ II/I)

3.079

1.920–4.937

0.000

2.956

1.838–4.754

0.000

 Age (≥ 65/< 65 years)

1.375

0.865–2.184

0.178

 Smoking (yes/no)

1.102

0.676–1.796

0.698

 TBX21 (high risk/low risk)

2.793

1.779–4.384

0.000

1.059

1.008–1.112

0.023