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Table 2 Univariate and multivariate Cox regression analysis for lung adenocarcinoma in validated datasets

From: TBX21 predicts prognosis of patients and drives cancer stem cell maintenance via the TBX21–IL-4 pathway in lung adenocarcinoma

Variable Univariate analysis Multivariate analysis
HR 95% CI P value HR 95% CI P value
GSE31210 (n = 159)
 Gender (male/female) 1.484 0.651–3.387 0.348    
 Stage (≥ II/I) 3.107 1.358–7.110 0.007 2.971 1.295–6.819 0.010
 Age (≥ 65/< 65 years) 1.854 0.813–4.231 0.142    
 Smoking (yes/No) 2.101 0.907–4.867 0.083   
 TBX21 (high risk/low risk) 4.550 1.960–10.560 0.000 1.018 1.002–1.035 0.028
GSE30219 (n = 71)
 Gender (male/female) 1.111 0.464–2.661 0.813    
 Stage (≥ II/I) 1.669 0.878–3.173 0.118   
 Age (≥ 65/< 65 years) 2.539 1.250–5.158 0.010 2.267 1.108–4.637 0.025
 TBX21 (high risk/low risk) 2.876 1.457–5.677 0.002 2.625 1.284–5.365 0.008
GSE68465 (n = 342)
 Gender (male/female) 1.376 1.008–1.878 0.044 1.425 1.033–1.965 0.031
 Stage (≥ II/I) 1.713 1.362–2.153 0.000 1.621 1.272–2.066 0.000
 Age (≥ 65/< 65 years) 1.266 0.928–1.726 0.137    
 Smoking (yes/no) 1.045 0.626–1.744 0.866   
 TBX21 (high risk/low risk) 2.147 1.561–2.952 0.000 1.009 1.007–1.012 0.000
GSE72094 (n = 302)
 Gender (male/female) 1.500 0.976–2.305 0.065    
 Stage (≥ II/I) 2.593 1.676–4.011 0.000 2.682 1.734–4.149 0.000
 Age (≥ 65/< 65 years) 1.485 0.882–2.501 0.137    
 Smoking (yes/no) 1.966 0.714–5.413 0.191   
 TBX21 (high risk/low risk) 1.424 1.091–1.859 0.009 1.469 1.127–1.914 0.004
TCGA LUAD (n = 399)
 Gender (male/female) 0.943 0.601–1.480 0.798    
 Stage (≥ II/I) 3.079 1.920–4.937 0.000 2.956 1.838–4.754 0.000
 Age (≥ 65/< 65 years) 1.375 0.865–2.184 0.178    
 Smoking (yes/no) 1.102 0.676–1.796 0.698   
 TBX21 (high risk/low risk) 2.793 1.779–4.384 0.000 1.059 1.008–1.112 0.023
  1. HR hazard ratio, CI confidence interval, LUAD lung adenocarcinoma, TCGA The Cancer Genome Atlas