Fig. 2From: Stem cell-derived mitochondria transplantation: a novel strategy and the challenges for the treatment of tissue injuryMechanism of stem cell therapy. Stem cells became potential therapy for cell injury via various kinds of mechanisms. After cell injury, stem cells proliferate and migrate to damaged areas and then differentiate into degenerated somatic cells. Besides that, stem cells inhibit inflammatory effects that further damage nearby cells and remove toxic compounds accumulated via injured cells. In addition, growth factors that support cellular growth are released by stem cells. Importantly, healthy mitochondria derived from stem cells can transfer into injured cells to replace damaged mitochondria via TNTs or endocytosis. ATP adenosine triphosphateBack to article page