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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: DNA topoisomerase IIβ stimulates neurite outgrowth in neural differentiated human mesenchymal stem cells through regulation of Rho-GTPases (RhoA/Rock2 pathway) and Nurr1 expression

Fig. 1

Neural differentiation of hMSCs with the mN3 cytokine combination. A Undifferentiated hMSCs (control, a), neural differentiated hMSCs at day 1 (b), day 3 (c) and day 5 (d). mN3 treatment induced hMSC cellular differentiation characterized by a polar appearance with long, out-branching axons. B Immunostaining of neural differentiated hMSCs at day 5 with the neural markers neurofilament (NF), Tau, and microtubule-associated protein (MAP2). mN3 treatment induced the expression of neural differentiation markers (images ×10)

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Stem Cell Research & Therapy

ISSN: 1757-6512