Fig. 3

hUC MSC secretome treatment reverses PH and RV hypertrophy in hyperoxia-induced lung injury. a Echocardiography shows reversal of cardiac dysfunction on MSC-CM treatment in the BPD mouse model. The white line in the echocardiogram depicts PAAT values for the specific group, where PAAT is the pulmonary artery acceleration time. b Graph demonstrating PAAT values from the five experimental groups at PN14. c Graph depicting PAAT/PAET ratio where PAET is the pulmonary artery ejection time. d Histogram showing the RV to LV ratio in the five experimental groups. e Fulton’s index [RV/(LV + IVS)], reflecting right ventricular hypertrophy, in the five experimental groups at PN14. f Echocardiography shows reversal of cardiac dysfunction on MSC-CM EXO treatment in the BPD mouse model. The white line in the echocardiogram depicts PAAT values for the specific group. g Graph demonstrating PAAT values from the five experimental groups at PN14. h Graph depicting PAAT/PAET ratio where PAET is the pulmonary artery ejection time. i Histogram showing the RV to LV ratio in the five experimental groups. j Fulton’s index [RV/(LV + IVS)], reflecting right ventricular hypertrophy, in the five experimental groups at PN14. All values are expressed as mean ± standard error of the mean (SEM); 5 experiments, N = 3–7 mice per group; one-way ANOVA with Tukey’s post hoc correction; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. BPD bronchopulmonary dysplasia, CM conditioned medium, EXO exosomes, IVS interventricular septa, LV left ventricular, MSC mesenchymal stem cell, PAAT pulmonary artery acceleration time, PAET pulmonary artery ejection time, PBS phosphate-buffered saline, RA room air, RV right ventricular