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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Human mesenchymal stem cell-derived extracellular vesicles/estrogen combined therapy safely ameliorates experimentally induced intrauterine adhesions in a female rat model

Fig. 3

Masson’s trichrome staining of uterine sections was performed to assess the extension of fibrosis in an injured endometrium in an IUA model with/without treatment. Stained tissue sections revealed that the endometrial stroma in group I (control) had almost no collagen fiber deposition (a). However, groups II (IUAs) and III (IUAs + estrogen) showed a marked increase in collagen fiber deposition (b, c). Groups IV (IUAs + hUCMSCs-EVs) and V (IUAs + estrogen + hUCMSCs-EVs) showed a decrease in the amount of collagen fiber deposition in the endometrium (d, e). Box blot showing the mean area percentage of collagen fibers in all groups (f). Data are expressed as the mean ± SD, n = 5. Curved arrows indicate the collagen fiber deposition

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Stem Cell Research & Therapy

ISSN: 1757-6512