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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Role of Notch1 in the arterial specification and angiogenic potential of mouse embryonic stem cell-derived endothelial cells

Fig. 5

Effects of Notch1 activation on angiogenic properties of ESC-derived arterial ECs in vitro. a Effects of ICN1 induction on tube-forming ability of iICN1-ECs pretreated with (+) or without (–) Dox for 3 days. Tube networks stained with Calcein AM. Scale bars: 100 μm. b Quantification of data in (a). Data represent mean ± SD (n = 3). ***p < 0.001 vs Dox–. c Notch1-induced migration of iICN1-ECs. iICN1-ECs treated with or without Dox for 3 days, and migration abilities of the cells measured using Transwell migration assay in response to 10 ng/chemotactic ml VEGF. Scale bar: 50 μm. d Effects of ICN1 induction on EC migration quantified. Data represent mean ± SD (n = 9). *p < 0.05 vs Dox–. Dox doxycycline

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Stem Cell Research & Therapy

ISSN: 1757-6512