Fig. 11
From: The march of pluripotent stem cells in cardiovascular regenerative medicine
a Different action potential phenotypes recorded from hESC-CMs. Figure reproduced with permission of Rao and colleagues. Phenotype and developmental potential of cardiomyocytes from induced pluripotent stem cells and human embryonic stem cells. In: Ainscough J. et al. eds. Nuclear reprogramming and stem cells. Humana Press, 2011 (159). b Diagram of an idealized adult human ventricular action potential. The phases of the action potential are labeled (phases 0–4). The predominant cardiac ion currents at each point in the action potential are labeled (INa = sodium current, Ito = transient outward potassium current, ICa = calcium current, IKr = rapidly activating delayed rectifier potassium current, IKs = slowly activating delayed rectifier potassium current, IK1 = inward rectifier potassium current). Figure reproduced with permission of Rao and colleagues. Phenotype and developmental potential of cardiomyocytes from induced pluripotent stem cells and human embryonic stem cells. In: Ainscough J. et al. eds. Nuclear reprogramming and stem cells. Humana Press, 2011 (159). CM cardiomyocyte, hESC human embryonic stem cell, iPSC induced pluripotent stem cells