Fig. 12
From: The march of pluripotent stem cells in cardiovascular regenerative medicine
Application of hiPSC technology in cardiovascular medicine. Fibroblasts can be obtained from skin biopsies and derived into iPSCs in vitro as previously discussed. iPSC differentiation into CMs allows the study of the cellular and mechanical aspects of a variety of genetic diseases. In vitro drug screening for reversion of the particular affliction can be tested on such “diseased” CMs. When derived from healthy donors, iPSCs and CMs can be used to test the cardiac toxicity of drugs. The use of “healthy” iPSC-CMs for cellular therapy is also considered as a potential application of iPSC technology in regenerative medicine. CM cardiomyocyte, iPSC induced pluripotent stem cell