Table 1 Study design and time schedule for the intervention

Verification of the selection criteria, information given to the patient, patient records and informed consent obtained

X

Panoramic X-ray scans

X

X

X

X

Loco-regional clinical examination

X

X

X

X

X

X

X

Impression of both dental arches

X

X

Facial and oral cavity photographs

X

X

Dental radiographs

X

X

X

X

VAS score for pain

X

X

X

X

X

Questionnaire on use of painkillers

X

X

X

X

X

Bone marrow harvest

X

Grafting procedure

X

CBCT scan

X

X

X

X

Implant placement, bone biopsy

X

Resonance frequency Analysis (ISQ RFA)

X

X

X

Implant loading (prosthesis)

X

Adverse events, clinical examination

X

X

X

X

X

X