Fig. 5
From: The effect of acute respiratory distress syndrome on bone marrow-derived mesenchymal stem cells
Gene expression of MSCs from the different groups after LPS treatment. Significant downregulation of high-mobility group box 1 (HMGB1) and Toll-like receptor (TLR)-4 genes in ‘Injured’ MSCs compared with ‘Uninjured’ MSCs (p < 0.01). Additionally, downregulation of angiopoietin 1 (Ang-1) and vascular endothelial growth factor (VEGF) genes in ‘Injured Untreated’ MSCs compared with ‘Injured Treated’ and ‘Uninjured’ MSCs, respectively (p < 0.05). Within each group, lipopolysaccharide (LPS) exposure induced significant downregulation of HMGB1 (p < 0.0001) and TLR-4 (p < 0.01) genes in ‘Injured’ MSC compared with upregulation in ‘Uninjured’ MSCs. For angiogenic genes, VEGF was upregulated in both ‘Uninjured’ and ‘Injured Treated’ MSCs (p < 0.0001) while Ang-1 was upregulated in ‘Injured Treated’ MSCs only (p < 0.05). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. RQ relative quotient, SOX-2 sex determining region Y-box 2