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Table 1 Functional properties of MSCs from the three different groups

From: The effect of acute respiratory distress syndrome on bone marrow-derived mesenchymal stem cells

  Uninjured Injured Untreated Injured Treated
MSC markers +++ +++ +++
Differentiation +++ +++ +++
Clonogenicity + +++ +
Proliferation +++ +++ +
Metabolism +++ +++ +
Secretion: MSCs +++ + +
Gene expression +++ + ++
Secretion: MSCs + MNCs +++ + +
  1. Mesenchymal stem cell (MSC) markers are for CD29+, CD90+, CD105+, and CD45−
  2. MSC differentiation is for osteoblasts, adipocytes, and chondrocytes
  3. MSC secretion is in reponse to LPS for IL-1β, IL-6, IL-8, IL-10, and TNF-α
  4. Gene expression is for HMGB1, TLR-4, SOX2, ANG-1, and VEGF
  5. MSC + mononuclear cell (MNC) secretion is for GM-CSF, IFN-γ, IL-1α, IL-1β, IL-1ra, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-18, and TNF-α
  6. +++ high levels, ++ intermediate levels, + low levels
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Stem Cell Research & Therapy

ISSN: 1757-6512