| Uninjured | Injured Untreated | Injured Treated |
---|
MSC markers | +++ | +++ | +++ |
Differentiation | +++ | +++ | +++ |
Clonogenicity | + | +++ | + |
Proliferation | +++ | +++ | + |
Metabolism | +++ | +++ | + |
Secretion: MSCs | +++ | + | + |
Gene expression | +++ | + | ++ |
Secretion: MSCs + MNCs | +++ | + | + |
- Mesenchymal stem cell (MSC) markers are for CD29+, CD90+, CD105+, and CD45−
- MSC differentiation is for osteoblasts, adipocytes, and chondrocytes
- MSC secretion is in reponse to LPS for IL-1β, IL-6, IL-8, IL-10, and TNF-α
- Gene expression is for HMGB1, TLR-4, SOX2, ANG-1, and VEGF
- MSC + mononuclear cell (MNC) secretion is for GM-CSF, IFN-γ, IL-1α, IL-1β, IL-1ra, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-18, and TNF-α
- +++ high levels, ++ intermediate levels, + low levels